View the Cn3D image
Peptide Name
Adiponectin precursor
Synonym
30 kDa adipocyte complement-related protein,ACRP30,Adipocyte specific protein AdipoQ,
Swiss ID
APM1_MOUSE
Gene Name
APM1 OR ACRP30 OR ADIPOQ.
Comment
FUNCTION: important negative regulator in hematopoiesis and immune systems; may be involved in ending inflammatory responses through its inhibitory functions. inhibits endothelial nf-kappab signaling through a camp-dependent pathway. inhibits tnf-alpha-induced expression of endothelial adhesion molecules (by similarity).
SUBUNIT: homooligomer.
SUBCELLULAR LOCATION: secreted in plasma.
TISSUE SPECIFICITY: synthesized exclusively by adipocytes and secreted into serum.
INDUCTION: during hormone-induced adipose differentiation and activated by insulin.
SIMILARITY: contains a collagenous domain.
SIMILARITY: contains 1 c1q domain
Sequence Comment
1-17
SIGNAL
POTENTIAL.
18-247
CHAIN
ADIPONECTIN.
45-110
DOMAIN
COLLAGEN-LIKE.
111-247
DOMAIN
C1Q.
39-39
DISULFID
INTERCHAIN (BY SIMILARITY).
47-47
MOD_RES
HYDROXYLATION (BY SIMILARITY).
50-50
MOD_RES
HYDROXYLATION (BY SIMILARITY).
56-56
MOD_RES
HYDROXYLATION (BY SIMILARITY).
65-65
MOD_RES
HYDROXYLATION (BY SIMILARITY).
79-79
MOD_RES
HYDROXYLATION (BY SIMILARITY).
98-98
MOD_RES
HYDROXYLATION (BY SIMILARITY).
107-107
MOD_RES
HYDROXYLATION (BY SIMILARITY).
113-113
VARIANT
M -> V.
50-50
CONFLICT
P -> S (IN REF. 2).
74-74
CONFLICT
A -> S (IN REF. 2).
117-117
CONFLICT
A -> G (IN REF. 2).
148-148
CONFLICT
G -> N (IN REF. 2).
243-243
CONFLICT
Y -> F (IN REF. 2).
Length
247AA
Molecular Weight
26841
Species:
Mus musculus (Mouse).
Sequence: 
        1    MLLLQALLFL LILPSHAEDD VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG RDGTPGEKGE KGDAGLLGPK GETGDVGMTG AEGPRGFPGT    100
      101    PGRKGEPGEA AYMYRSAFSV GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK KDKAVLFTYD QYQEKNVDQA    200
      201    SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTN