| Peptide Name |
Agouti related protein precursor. |
| Synonym |
None |
| Swiss ID |
AGSR_HUMAN |
| Gene Name |
AGRP OR ART OR AGRT. |
| Comment |
| FUNCTION: |
plays a role in weight homeostasis. may play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding. |
| SUBCELLULAR LOCATION: |
secreted (by similarity). |
| TISSUE SPECIFICITY: |
expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. |
| SIMILARITY: |
belongs to the agouti family |
|
| Reference
Review |
| 1. DESCRIPTION |
| DESCRIPTION The hypothalamic agouti-related protein (AGRP) regulates body weight via central melanocortin receptors (see 155555). |
|
| Sequence
Comment |
1-20 |
|
POTENTIAL. |
21-132 |
|
AGOUTI RELATED PROTEIN. |
87-129 |
|
CYS-RICH. |
87-102 |
|
|
94-108 |
|
|
101-119 |
|
|
105-129 |
|
|
110-117 |
|
|
6-6 |
|
V -> L (IN REF. 2). |
|
Length |
132AA |
Molecular
Weight |
14440 |
Species: |
Homo sapiens (Human). |
| Sequence: |
1 MLTAAVLSCA LLLALPATRG AQMGLAPMEG IRRPDQALLP ELPGLGLRAP LKKTTAEQAE EDLLQEAQAL AEVLDLQDRE PRSSRRCVRL HESCLGQQVP 100
101 CCDPCATCYC RFFNAFCYCR KLGTAMNPCS RT
|
|
|
