| Peptide Name |
ADM precursor [Contains: Adrenomedullin, Proadrenomedullin N-20 terminal peptide]. |
| Synonym |
AM,Proadrenomedullin N-20 terminal peptide (ProAM-N20,ProAM N-terminal 20 peptide,PAMP, |
| Swiss ID |
ADML_HUMAN |
| Gene Name |
ADM OR AM. |
| Comment |
| FUNCTION: |
am and pamp are potent hypotensive and vasodilatator agents. numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. in the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. in pituitary gland, both peptides at physiologically relevant doses inhibit basal acth secretion. both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. |
| SUBCELLULAR LOCATION: |
secreted. |
| TISSUE SPECIFICITY: |
highest levels found in pheochromocytoma and adrenal medulla. also found in lung, ventricle and kidney tissues. |
| SIMILARITY: |
belongs to the adrenomedullin family |
|
Sequence
Comment |
1-21 |
|
|
22-41 |
|
PROADRENOMEDULLIN N-20 TERMINAL PEPTIDE. |
45-92 |
|
|
95-146 |
|
ADRENOMEDULLIN. |
148-185 |
|
PREPROAM C-TERMINAL FRAGMENT. |
110-115 |
|
|
41-41 |
|
AMIDATION (G-42 PROVIDE AMIDE GROUP). |
146-146 |
|
AMIDATION (G-147 PROVIDE AMIDE GROUP). |
|
Length |
185AA |
Molecular
Weight |
20420 |
Species: |
Homo sapiens (Human). |
| Sequence: |
1 MKLVSVALMY LGSLAFLGAD TARLDVASEF RKKWNKWALS RGKRELRMSS SYPTGLADVK AGPAQTLIRP QDMKGASRSP EDSSPDAARI RVKRYRQSMN 100
101 NFQGLRSFGC RFGTCTVQKL AHQIYQFTDK DKDNVAPRSK ISPQGYGRRR RRSLPEAGPG RTLVSSKPQA HGAPAPPSGS APHFL
|
|
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